Users who updated to iTunes 12.8.1 were greeted with following error message when opening Safari on OS X Yosemite 10.10.5: “Safari cannot be opened because of a problem. Check with the developer to make sure Safari works with this version of Mac OS X. You may have to reinstall the application. Be sure to install any available updates for the application and Mac OS X. One Stack Exchange user was of the opinion that the iTunes 12.8.1 update is likely updating the MobileDevice.framework in /System/Library/PrivateFrameworks/ to a version incompatible with Safari 10.1.2. However, it now appears that Apple has pulled the iTunes 12.8.1 update. Some users have found a workaround to fix Safari. For that, you need to go the Finder app, click on Go > Go to Folder… in the top menu bar, typing in /System/Library/PrivateFrameworks/ and drag MobileDevice.framework to the Trash. Note: These steps have not been tested by us. Also Read- What is Mac OS? Pros and Cons Of Using It
